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Quantitative ultrasound screening of bone mineral density on children with short stature
Abdulmoein E Al-Agha1, Yousef O Kabli, Melissa G AlBeiruty
1Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail. aagha@kau.edu.sa.
Insights
Children with short stature exhibit lower bone mineral density (BMD) compared to normal-height peers. Vitamin D supplementation and age positively correlate with higher BMD in short children.
Area of Science:
- Pediatric endocrinology
- Bone health assessment
Background:
- Short stature in children can be associated with various underlying conditions.
- Assessing bone mineral density (BMD) is crucial for evaluating overall health in children.
- Quantitative ultrasound (QUS) offers a non-invasive method for BMD assessment.
Purpose of the Study:
- To evaluate bone mineral density (BMD) in children with short stature using quantitative ultrasound (QUS).
- To compare BMD in short-statured children with that of children of normal height.
- To identify factors associated with BMD variations in children with short stature.
Main Methods:
- A descriptive, cross-sectional controlled study was conducted in Jeddah, Saudi Arabia.
- 219 children participated: 100 with short stature and 119 with normal height.
- Bone mineral density (BMD) was measured using quantitative ultrasound (QUS).
Main Results:
- Children with short stature demonstrated significantly lower BMD z-scores than controls (p<0.05).
- Vitamin D supplementation was linked to higher BMD z-scores in short-statured children (p<0.05).
- Higher BMD z-scores correlated with increased age and height (p=0.05, p=0.02 respectively).
Conclusions:
- Children with short stature have lower bone mineral density (BMD) compared to normal-height children.
- Height, age, and vitamin D supplementation are significant positive correlates of BMD.
- Growth hormone deficiency showed a trend towards association with lower BMD (p=0.06).
Objectives:
To assess bone mineral density (BMD) of children with short stature using quantitative ultrasound (QUS) and compare it to children with normal height. Methods: We conducted a descriptive, cross-sectional controlled study between May 2018 and February 2019 at various pediatric clinics in Jeddah, Saudi Arabia. In total, 219 children were included: 100 had short stature, and 119 were of normal height. Data were collected from one-on-one interviews, and BMD was measured using quantitative ultrasound. Results: Children with short stature had significantly lower BMD z-scores than children with normal height (pless than 0.05). The use of vitamin D supplements was related to higher BMD z-scores in children with short stature (p less than 0.05). A significant association was found between higher BMD z-scores, and both age (p=0.05) and height (p=0.02). Through a further division of children with short stature into those with and those without growth hormone deficiencies, we show that growth hormone deficiency was positively associated with lower BMD z-scores; however, the p-value was 0.06. Conclusions: Compared with children of normal height, those with short stature had lower BMD. Height, vitamin D supplementation, and age were all significantly correlated with higher BMD, while growth hormone deficiency was correlated with lower BMD.
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