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Angiotensin Receptor Neprilysin Inhibitors-2019 Update

George Chalikias1, Dimitrios Tziakas2

  • 1Cardiology Department, Medical School, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece.

Cardiovascular Drugs and Therapy
|June 11, 2020
PubMed

Insights

Sacubitril/valsartan offers new benefits for chronic heart failure (CHF) patients. Recent evidence highlights early initiation and implementation strategies for this novel treatment.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Sacubitril/valsartan has emerged as a significant treatment for chronic heart failure (CHF) since the PARADIGM-HF study.
  • Annual publications provide extensive new data on its clinical application and outcomes.

Purpose of the Study:

  • To critically review and summarize recent evidence (2019 onwards) on sacubitril/valsartan in CHF.
  • To appraise new data concerning its real-world effectiveness, cost-effectiveness, and use in diverse patient populations.

Main Methods:

  • Systematic review of literature published from 2019 to present.
  • Categorization of new data into real-world evidence, RCTs, surrogate endpoints, cost-effectiveness, and specific clinical applications.

Main Results:

  • Early initiation of sacubitril/valsartan during hospitalization or post-discharge is crucial.
  • Identified barriers to implementation and analytical challenges in measuring natriuretic peptides.
  • Extrapolated use in populations beyond those studied in the PARADIGM-HF trial.

Conclusions:

  • Sacubitril/valsartan continues to demonstrate value in CHF management.
  • Evidence supports early adoption and highlights areas for improved implementation and future research.

Keywords:
2019Angiotensin receptor neprilysin inhibitorsSacubitrilUpdate

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