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Updated: Dec 18, 2025
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
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Internally functionalized multifaceted organochalcogen compounds
1UM-DAE Centre for Excellence in Basic Sciences, Nalanda Building, University of Mumbai, Kalina Campus, Santacruz (E), Mumbai-400 098, India. jainvk@cbs.ac.in.
Dalton Transactions (Cambridge, England : 2003)
|June 11, 2020
Summary
New organochalcogen compounds with nitrogen donors act as versatile hemilabile ligands. These ligands enable palladium catalysis and form metal chalcogenide nanomaterials, with some showing antioxidant activity.
Area of Science:
- Coordination Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Organochalcogen compounds with diverse backbones (flexible/rigid) and functional groups (N,N-dimethylaminoalkyl, pyridyl/pyrimidyl) were synthesized.
- These compounds possess both soft (chalcogen) and hard (nitrogen) donor atoms, classifying them as hemilabile ligands.
Purpose of the Study:
- To design and develop novel organochalcogen compounds with unique ligand properties.
- To explore their applications in homogeneous catalysis, nanomaterial synthesis, and biological activity.
Main Methods:
- Synthesis of internally functionalized organochalcogen compounds.
- Characterization of ligand chemistry and reactivity.
- Application in palladium-catalyzed C-C coupling reactions.
- Use as molecular precursors for metal chalcogenide nanomaterials and thin films.
- Evaluation of glutathione peroxidase (GPx) mimicking activity for selenium-based compounds.
Main Results:
- Designed organochalcogen compounds exhibit remarkable ligand behavior and reactivity.
- Palladium complexes with these hemilabile ligands are effective homogeneous catalysts for C-C coupling.
- Metal chalcogenolato complexes serve as precursors for metal chalcogenide nano-crystals and thin films.
- Selenium-based pyridyl and pyrimidyl compounds demonstrate promising GPx mimicking activity, influenced by C-3 substituents.
Conclusions:
- Developed organochalcogen compounds are versatile hemilabile ligands with broad applications.
- These ligands facilitate advancements in catalysis and materials science.
- The structural and electronic properties of these compounds are crucial for their catalytic and biological functions.
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