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Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

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Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Acid Halides to Alcohols: Grignard Reaction01:15

Acid Halides to Alcohols: Grignard Reaction

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Organomagnesium halides, commonly known as Grignard reagents, convert acid halides to tertiary alcohols. The reaction requires two equivalents of the Grignard reagent and proceeds via a ketone intermediate.
Grignard reagents are a source of carbanions and function as nucleophiles. The mechanism begins with the nucleophilic attack by the carbanion at the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs,...
2.8K
Introduction to Functional Groups02:08

Introduction to Functional Groups

34.1K

Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.  
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry....
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.0K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.0K
Structural Isomerism02:34

Structural Isomerism

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Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Internally functionalized multifaceted organochalcogen compounds.

Vimal K Jain1

  • 1UM-DAE Centre for Excellence in Basic Sciences, Nalanda Building, University of Mumbai, Kalina Campus, Santacruz (E), Mumbai-400 098, India. jainvk@cbs.ac.in.

Dalton Transactions (Cambridge, England : 2003)
|June 11, 2020
PubMed
Summary

New organochalcogen compounds with nitrogen donors act as versatile hemilabile ligands. These ligands enable palladium catalysis and form metal chalcogenide nanomaterials, with some showing antioxidant activity.

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Medicinal Chemistry

Background:

  • Organochalcogen compounds with diverse backbones (flexible/rigid) and functional groups (N,N-dimethylaminoalkyl, pyridyl/pyrimidyl) were synthesized.
  • These compounds possess both soft (chalcogen) and hard (nitrogen) donor atoms, classifying them as hemilabile ligands.

Purpose of the Study:

  • To design and develop novel organochalcogen compounds with unique ligand properties.
  • To explore their applications in homogeneous catalysis, nanomaterial synthesis, and biological activity.

Main Methods:

  • Synthesis of internally functionalized organochalcogen compounds.
  • Characterization of ligand chemistry and reactivity.
  • Application in palladium-catalyzed C-C coupling reactions.
  • Use as molecular precursors for metal chalcogenide nanomaterials and thin films.
  • Evaluation of glutathione peroxidase (GPx) mimicking activity for selenium-based compounds.

Main Results:

  • Designed organochalcogen compounds exhibit remarkable ligand behavior and reactivity.
  • Palladium complexes with these hemilabile ligands are effective homogeneous catalysts for C-C coupling.
  • Metal chalcogenolato complexes serve as precursors for metal chalcogenide nano-crystals and thin films.
  • Selenium-based pyridyl and pyrimidyl compounds demonstrate promising GPx mimicking activity, influenced by C-3 substituents.

Conclusions:

  • Developed organochalcogen compounds are versatile hemilabile ligands with broad applications.
  • These ligands facilitate advancements in catalysis and materials science.
  • The structural and electronic properties of these compounds are crucial for their catalytic and biological functions.