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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Clinical impact of a single time-point protocol paired FDG-PET and radioactive iodine scan for comprehensive disease assessment in differentiated thyroid cancer.

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Glucagon-like peptide-1 receptor (GLP-1R) overexpression defines a distinct immunogenetic subset in primary and metastatic thyroid cancer: implications for GLP-1R agonist therapy.

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Erythroferrone Modulates Osteoblast-Osteoclast Crosstalk During Bone Remodeling.

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Related Experiment Video

Updated: Dec 18, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

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Beyond bone biology: Lessons from team science.

Mone Zaidi1, Daria Lizneva1, Sakshi Gera1

  • 1The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|June 11, 2020
PubMed
Summary

Collaborative team science is crucial for modern biomedical research, integrating diverse expertise. This approach expands research boundaries beyond traditional disciplines, fostering innovation.

Keywords:
biomarkersbonecell and molecular imagingmetabolic bone diseaseosteoporosis

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Area of Science:

  • Biomedical research
  • Team science
  • Interdisciplinary studies

Background:

  • Modern biomedical research increasingly demands knowledge and technologies from multiple fields.
  • Traditional disciplinary boundaries limit comprehensive scientific inquiry.
  • The need for collaborative, cross-disciplinary approaches is growing.

Purpose of the Study:

  • To share lessons learned from interdisciplinary and transdisciplinary research teams.
  • To illustrate the benefits of expanding research scope through collaboration.
  • To highlight the expansion of research beyond a single biological focus.

Main Methods:

  • Review of experiences within interdisciplinary research teams.
  • Analysis of outcomes from transdisciplinary research collaborations.
  • Reflection on the process of broadening research areas.

Main Results:

  • Successful expansion of research capabilities through collaborative efforts.
  • Demonstration of how diverse expertise enhances scientific discovery.
  • Insights gained from navigating cross-disciplinary research dynamics.

Conclusions:

  • Interdisciplinary and transdisciplinary team science are essential for advancing biomedical research.
  • Collaboration across fields enables researchers to overcome limitations of single disciplines.
  • Adopting team science approaches facilitates significant expansion of research frontiers.