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Published on: December 27, 2016
Antibacterial Anacardic Acid Derivatives
Marco Saedtler1, Niclas Förtig1, Knut Ohlsen2
1Institute for Pharmacy and Food Chemistry, Am Hubland, 97074 Würzburg, Germany.
Abstract:
We report on the antibacterial activity of five phenolic lipids derived from anacardic acid characterized by increasing alkyl chain lengths with 6, 8, 10, 12, or 14 carbon atoms. The compounds were profiled for their physicochemical properties, transport across epithelial monolayers, cytotoxicity, and antibacterial activity as compared to common antibiotics. No cytotoxicity was reported in cell lines of fibroblast, hepatic, colorectal, or renal origin. C and C significantly increased the survival in a Galleria mellonella model infected with multi-drug-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococci (VRE) as compared to the untreated control group. Future studies are required to corroborate these findings in relevant animal model systems of infection.
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