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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Updated: Dec 18, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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[Theranostics and differentiated thyroid cancer].

Emese Mezősi1

  • 1I. Sz. Belgyógyászati Klinika, Pécsi Tudományegyetem, Klinikai Központ, Általános Orvostudományi Kar, Pécs, Hungary. mezosi.emese@pte.hu.

Magyar Onkologia
|June 11, 2020
PubMed
Summary

Radioactive iodine (I-131) remains crucial for differentiated thyroid cancer (DTC) treatment. New guidelines and classifications aim to refine I-131 therapy indications, reducing overtreatment and improving patient outcomes.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Endocrinology

Background:

  • Radioactive iodine (I-131) is a foundational theranostic agent for differentiated thyroid cancer (DTC).
  • I-131 therapy targets cancer cells via sodium iodide symporter-mediated uptake, contributing to favorable DTC prognosis.
  • Increasing DTC incidence necessitates updated management strategies to prevent overtreatment.

Purpose of the Study:

  • To summarize recent recommendations for differentiated thyroid cancer management.
  • To focus on updated indications for radioiodine therapy in DTC.
  • To review proposals from the Hungarian consensus conference on DTC management.

Main Methods:

  • Literature review of current DTC management guidelines.
  • Analysis of new pathological classification and staging systems for DTC.

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  • Examination of expert consensus and recommendations regarding radioiodine therapy.

    • Main Results:

    • Differentiated thyroid cancer incidence is rising globally.
    • New classifications and staging systems are emerging for DTC.
    • There is a trend towards less radical therapeutic approaches in DTC management.

    Conclusions:

    • Refined indications for radioiodine therapy are crucial for optimizing DTC treatment.
    • Updated guidelines aim to balance therapeutic efficacy with minimizing side effects and overtreatment.
    • The Hungarian consensus conference provides specific proposals for current DTC management.