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Related Experiment Video

Updated: Dec 18, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
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[Theranostics in prostate cancer].

Ildikó Garai1, Gábor Nagy1, Ferenc Bátyi1

  • 1Scanomed Orvosi, Diagnosztikai, Kutató és Oktató Kft., Debrecen, Hungary. garai@belklinika.com.

Magyar Onkologia
|June 11, 2020
PubMed
Summary
This summary is machine-generated.

PSMA radioligand therapy offers advanced prostate cancer management. This theranostic approach uses diagnostic imaging and targeted radionuclide therapy for improved detection and treatment of metastatic disease.

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiochemistry

Background:

  • Radiochemistry and hybrid technology have revolutionized prostate cancer management.
  • Choline PET offers sensitive diagnosis, aiding personalized, metastases-directed therapies.
  • PSMA radioligands are established theranostics globally, but not yet in Hungary.

Purpose of the Study:

  • To review Prostate-Specific Membrane Antigen (PSMA) radioligand therapy (PRLT) for prostate cancer management.
  • To highlight the diagnostic and therapeutic potential of PSMA radioligands.
  • To present findings based on the recent European guideline for PRLT.

Main Methods:

  • Review of recent European guidelines on PSMA radioligand therapy.
  • Analysis of diagnostic capabilities of 68Ga- or 18F-labelled PSMA molecules.
  • Evaluation of therapeutic efficacy of 177Lu-labelled PSMA ligands.

Main Results:

  • PSMA-based PET imaging is more sensitive than choline PET for detecting primary prostate cancer and metastases, especially at low PSA levels.
  • 177Lu-labelled PSMA ligands provide an effective therapeutic option for metastatic castration-resistant prostate cancer.
  • PSMA radioligands represent a significant advancement in theranostics for prostate cancer.

Conclusions:

  • PSMA radioligand therapy is a promising theranostic approach for prostate cancer.
  • PRLT enhances diagnostic accuracy and therapeutic effectiveness in advanced prostate cancer.
  • The review provides a basis for understanding and implementing PRLT in clinical practice.