Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry
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Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
Published on: September 29, 2016
Alessia Battigelli1, Bethany Almeida1, Shashank Shukla1
1School of Engineering, Center for Biomedical Engineering, Institute for Molecular and Nanoscale Innovation, Brown University, Providence, Rhode Island 02912, USA. anita_shukla@brown.edu.
Abstract:
We introduce an innovative approach to adhere mesenchymal stem cells (MSCs) to a hydrogel scaffold by nucleating adhesion through strain-promoted click chemistry. This method yields a significant increase in cell viability compared to non-functionalized and RGD peptide functionalized hydrogels, providing a promising alternative to traditional biomaterials cell attachment approaches.
