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Updated: Dec 18, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
[Cancer immunotherapy: from inception to Nobel Prize]
Liliana Vasquez1, Denisse Castro1, Joel de León2
1Centro de Investigación de Medicina de Precisión, Instituto de Investigación, Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima, Perú.
Abstract:
Immunotherapy has meant a great scientific advance in the treatment of cancer in recent years, being considered as the therapeutic cornerstone of some neoplasms. However, in some types of cancer only a fraction of patients achieve benefit, posing the challenges and limitations that lead us to the need to understand the complexity of tumor biology, the microenvironment and the responsiveness of each agent. The results currently exceed what was achieved by conventional chemotherapy, although it is not yet possible to determine whether these responses are lasting or represent cure. In this review, a broad approach to immunotherapy in cancer is proposed, from the basics to its clinical application, a discovery that was awarded the Nobel Prize in Medicine in 2018.
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