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Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
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Related Experiment Video

Updated: Dec 18, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
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JAK selectivity: more precision less troubles.

Giulia Roda1, Arianna Dal Buono1, Marjorie Argollo2

  • 1IBD Unit, Humanitas Clinical and Research Center - IRCCS - , Milan, Italy.

Expert Review of Gastroenterology & Hepatology
|June 11, 2020
PubMed
Summary
This summary is machine-generated.

Janus kinase inhibitors (JAKi) offer a promising new treatment for Inflammatory Bowel Disease (IBD). Their selectivity is changing IBD treatment, with encouraging efficacy and safety data.

Keywords:
Janus KinaseKey-words: inflammatory bowel diseaseefficacysafetyselectivity

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Area of Science:

  • Immunology
  • Gastroenterology
  • Pharmacology

Background:

  • Janus kinase inhibitors (JAKi) are novel small molecules for Inflammatory Bowel Disease (IBD) treatment.
  • Janus Kinases (JAK) are key in regulating inflammatory gene transcription relevant to IBD.

Purpose of the Study:

  • To review the latest developments in JAK inhibitors for IBD.
  • To discuss how JAK inhibitor selectivity impacts the course of IBD.

Main Methods:

  • Comprehensive literature search for studies on JAK inhibitors and IBD.
  • Analysis of current data on JAK inhibitor efficacy and safety in IBD.

Main Results:

  • Efficacy and safety data for JAK inhibitors in IBD are highly encouraging.
  • Selective JAK inhibitors demonstrate potential to alter IBD progression.

Conclusions:

  • JAK inhibitors represent a significant advancement in IBD therapeutics.
  • Due to their selectivity and positive data, JAK inhibitors may become a primary treatment option for IBD.