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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

789
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

Updated: Dec 18, 2025

Orthotopic Hind Limb Transplantation in the Mouse
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Precision transplant pathology.

Michelle A Wood-Trageser1,2, Qinyong Xu1,2, Adriana Zeevi1,2

  • 1Thomas E. Starzl Transplantation Institute, University of Pittsburgh.

Current Opinion in Organ Transplantation
|June 11, 2020
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Summary

Next-generation sequencing and pathology enhance organ transplant matching and monitoring. These advanced tools improve donor-recipient compatibility and track specific antibodies for better allograft care.

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Area of Science:

  • Transplant pathology
  • Immunogenetics
  • Histopathology

Background:

  • Transplant pathology is crucial for personalized treatment of organ allograft recipients.
  • Next-generation sequencing and pathology are rapidly advancing.
  • These advancements improve donor/recipient matching and allograft monitoring.

Purpose of the Study:

  • To summarize the workflow of a patient through a pathology practice.
  • To highlight evolving areas in histocompatibility assessment and tissue pathology.
  • To emphasize critical needs within the field of transplant pathology.

Main Methods:

  • Utilizing next-generation sequencing for high-resolution donor-recipient matching and eplet mismatch scores.
  • Employing multiplex labeling and machine learning to transform histopathology.
  • Integrating traditional lab tests with advanced molecular platforms (-omics).

Main Results:

  • Next-generation sequencing enables precise monitoring of donor-specific antibodies (DSAs).
  • Combined approaches allow for risk stratification and early detection of subclinical changes.
  • Advanced techniques transform traditional histopathology.

Conclusions:

  • Precise donor-recipient histocompatibility matching is essential for successful transplantation.
  • Integrated data platforms are needed for accurate allograft health assessment.
  • Software integration is critical for optimizing immunosuppression adjustments.