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Related Experiment Video

Updated: Dec 18, 2025

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.4K

A modified mouse-tail lymphedema model.

G Arruda1, S Ariga1, T M de Lima1

  • 1Emergency Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, Brazil.

Lymphology
|June 11, 2020
PubMed
Summary
This summary is machine-generated.

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Researchers developed a modified mouse tail model for lymphedema, offering a faster and easier way to study this condition. Both the original and modified models effectively induce lymphedema, showing similar pathological changes.

Area of Science:

  • Vascular Biology
  • Surgical Pathology
  • Animal Models

Background:

  • Studying lymphedema pathophysiology is hindered by a lack of suitable experimental models.
  • Previous mouse tail methods exist but require refinement for ease of use.

Purpose of the Study:

  • To modify an existing mouse tail lymphedema model for improved experimental efficiency.
  • To compare the efficacy of a modified model against the original technique in inducing lymphedema.

Main Methods:

  • A modified mouse tail ligation technique was developed and compared to a previously described method.
  • Twenty mice underwent each technique, with tissue samples collected at 3 and 6 weeks post-operation.
  • Histological analysis (Oil red O) and molecular markers (lipin 1/2, SLP76, F4-80) assessed lymphedema progression.
Keywords:
histologylymphedemamolecular markersmouse modelsignaling pathways

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Related Experiment Videos

Last Updated: Dec 18, 2025

A Murine Tail Lymphedema Model
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A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.4K
A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

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Main Results:

  • Both the original and modified mouse tail models successfully induced lymphedema.
  • Lymphedema was characterized by lymphatic dilation, edema, inflammation, and adipose tissue deposition.
  • Adipogenesis, lymphangiogenesis, and inflammation markers were significantly increased in both models by 6 weeks.

Conclusions:

  • Both the original and modified mouse tail models are reliable for studying lymphedema pathophysiology.
  • The modified technique offers a faster, easier, and consistent alternative for lymphedema research.