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Association between maternal serum uric acid and preeclampsia
Amir Shakarami1, Masoumeh Ghafarzadeh2, Fatemeh Yari3
1Department of Cardiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Archives of Physiology and Biochemistry
|June 11, 2020
Summary
Serum uric acid levels are significantly higher in preeclamptic pregnancies compared to healthy ones. Elevated uric acid may indicate an increased risk of developing preeclampsia during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Clinical Chemistry
Background:
- Preeclampsia is a serious pregnancy complication characterized by high blood pressure.
- Serum uric acid is a metabolic byproduct that has been implicated in various conditions.
Purpose of the Study:
- To investigate and compare serum uric acid levels in preeclamptic versus normotensive pregnant women.
- To determine if serum uric acid levels can serve as a predictive marker for preeclampsia.
Main Methods:
- A comparative analysis of serum uric acid levels was performed.
- Two hundred and twenty-four pregnant women were enrolled, divided into preeclamptic and healthy groups.
- Measurements were taken at referral and before delivery.
Main Results:
- Mean serum uric acid was significantly higher in preeclamptic women (6.51 mg/dL) than in normotensive women (4.72 mg/dL).
- Elevated serum uric acid levels were associated with a 1.98-fold increased risk of preeclampsia.
- Maternal age, gestational age, and BMI did not show significant correlations with uric acid levels.
Conclusions:
- Pregnant women with preeclampsia exhibit significantly elevated serum uric acid levels compared to normotensive controls.
- Serum uric acid is a potential significant indicator for the early detection and risk assessment of preeclampsia.
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