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[Antimicrobial activity of antiseptics]
1Cumhuriyet Universitesi, Tip Fakültesi, Mikrobiyoloji Anabilim Dali, Sivas.
Mikrobiyoloji Bulteni
|January 1, 1988
Summary
Antimicrobial agents like povidone-iodine and chlorhexidine gluconate showed increased efficacy over time against bacteria and fungi. Soap lacked germicidal effects, and hand antiseptic persistence was statistically insignificant after two hours.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Healthcare-associated infections necessitate effective antimicrobial agents.
- Understanding the temporal activity of disinfectants is crucial for infection control.
Purpose of the Study:
- To evaluate and compare the antimicrobial efficacy of various disinfectants over time.
- To assess the impact of time on the germicidal activity of antiseptics.
Main Methods:
- Comparative analysis of antimicrobial activities of povidone-iodine, chlorhexidine gluconate, benzalconium chloride, detergent, and soap.
- In vitro testing against Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter cloacae, and Candida strains.
- Evaluation of germicidal effect changes over time and assessment of antiseptic persistence on hands.
Main Results:
- Antimicrobial activity of tested germicides increased with time against the studied microorganisms.
- Soap exhibited no significant germicidal effect.
- No statistically significant difference was observed in antiseptic efficacy on hand flora immediately versus two hours post-application.
Conclusions:
- The efficacy of common antimicrobial agents enhances over time, suggesting prolonged contact may improve outcomes.
- Soap is ineffective as a germicide.
- The residual antimicrobial effect of hand antiseptics on the skin is short-lived.