From Young to Old: AMPylation Hits the Brain

Area of Science:

• Biochemistry
• Molecular Biology
• Neuroscience

Background:

• Protein post-translational modifications (PTMs) are crucial for cellular regulation.
• AMPylation is an emerging PTM involved in neurodevelopment and metabolic pathways.
• FICD and SELO are identified AMPylating enzymes in metazoans.

Purpose of the Study:

• To summarize current knowledge on protein AMPylation.
• To highlight the roles of FICD and SELO in cellular processes.
• To outline future research directions for AMPylation.

Main Methods:

• Biochemical studies
• Chemical proteomics
• Literature review and synthesis

Main Results:

• AMPylation regulates neurodevelopment and neurodegeneration.
• AMPylation impacts diverse metabolic pathways.
• FICD and SELO are involved in unfolded protein response, redox homeostasis, and glial/neuronal development.

Conclusions:

• Protein AMPylation is a significant PTM with broad physiological implications.
• Further research into AMPylation, its enzymes, and its link to toxic protein aggregation is warranted.
• Understanding AMPylation offers potential therapeutic avenues for neurological disorders.