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Related Experiment Video

Updated: Dec 18, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
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Association between Family Functionality and Depression: A Systematic Review and Meta-Analysis.

Daniel Guerrero-Muñoz1, Diana Salazar1, Victoria Constain1

  • 1Department of Family Medicine, Universidad del Valle, Cali, Colombia.

Korean Journal of Family Medicine
|June 11, 2020
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Summary
This summary is machine-generated.

Family dysfunction significantly increases the risk of depression. This systematic review found a strong association, highlighting the importance of family environment in mental health outcomes.

Keywords:
Apgar ScoreDepressionFamily DysfunctionMeta-AnalysisSystematic Review

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Area of Science:

  • Family dynamics and mental health research.
  • Clinical psychology and psychiatry.

Background:

  • Family functioning impacts health outcomes and predicts depression.
  • Assessing family dynamics is crucial for understanding mental well-being.

Purpose of the Study:

  • To systematically review and meta-analyze studies on the association between family functionality and depression.
  • To quantify the relationship between family dysfunction and depressive symptoms.

Main Methods:

  • Systematic review and meta-analysis of cross-sectional, cohort, and case-control studies.
  • Searched MEDLINE, Embase, Central, and LILACS databases, including unpublished literature.
  • Utilized validated instruments like Family APGAR and FAD-EC III; analyzed data using Review Manager with forest plots and fixed-effect models.

Main Results:

  • 10 studies included in qualitative synthesis; 4 in meta-analysis from 1,519 initial studies.
  • Family dysfunction showed a significant association with depression, with an Odds Ratio (OR) of 3.72 (95% CI: 2.70 to 5.12).
  • Low heterogeneity observed (I2 = 24%).

Conclusions:

  • Family dysfunction is strongly associated with depression.
  • Interventions addressing family dynamics may play a role in preventing or treating depression.