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Updated: Dec 18, 2025
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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mdm2 oncogene in laryngeal squamous cell carcinoma
Nicholas Mastronikolis1, Vasileios Ragos, Panagiotis Fotiades
1Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Patras.
Summary
Mouse double minute 2 homolog (mdm2) is a proto-oncogene implicated in laryngeal squamous cell carcinoma (LSCC) progression. This review explores mdm2
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Laryngeal squamous cell carcinoma (LSCC) incidence is rising globally, linked to High Risk Human Papilloma Virus (HR HPV), smoking, and alcohol.
- Malignant transformation involves chromosomal aberrations and gene mutations, with proto-oncogenes like mdm2 playing a key role.
- Mdm2 (mouse double minute 2 homolog) is an E3 ubiquitin ligase regulating the p53 tumor suppressor pathway.
Purpose of the Study:
- To review the role and specific aspects of the mdm2 gene in the development and progression of LSCC.
- To highlight mdm2 as a potential biomarker for LSCC biological behavior.
Main Methods:
- This study is a molecular review, synthesizing existing research on mdm2 in LSCC.
- Literature search focused on mdm2 gene function, its interaction with p53, and its implications in various cancers, particularly LSCC.
Main Results:
- Mdm2 directly binds to and inhibits the tumor suppressor activity of p53.
- Aberrant overexpression of mdm2 is common in several cancers, including breast carcinoma.
- Limited data currently exists on mdm2's specific role and prevalence in LSCC.
Conclusions:
- Mdm2 is a significant proto-oncogene with a critical role in regulating p53, a key tumor suppressor.
- Further investigation into mdm2's function and overexpression in LSCC is warranted.
- Mdm2 may serve as a valuable marker for understanding LSCC's biological behavior and potential therapeutic targeting.
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