Maternal Altitude-Corrected Hemoglobin and at Term Neonatal Anthropometry at 3400 m of Altitude

Villamonte-Calanche, Wilfredo, Nelly Lam-Figueroa, Maria Jerí-Palomino, Cleto De-La-Torre, and Alexandra A. Villamonte-Jerí. Maternal altitude-corrected hemoglobin and at term neonatal anthropometry at 3400 m of altitude. High Alt Med Biol. 21:287-291, 2020. Fetal growth is prominent in the last trimester of pregnancy. The development of the fetus depends on the nutrient consumption and oxygen delivery of the pregnant woman. Therefore, maternal anemia has an inverse relationship with fetal growth. Consequently, the newborn has lower anthropometric measurements. Residing in places of a high altitude increases the level of hemoglobin (Hb); as a result, the World Health Organization (WHO) recommends adjusting the value of Hb in maternal blood at 3400-m altitude by reducing 2.4 g/dL to obtain the corrected Hb (HbCorr). To determine if the relationship of maternal HbCorr for high altitude is related to term neonatal anthropometry at 3400-m altitude. We performed a retrospective cohort study and evaluated the neonatal anthropometric variables (weight, ponderal index, head circumference [HC], and HC for birthweight index) in 308 exposed pregnant women (HbCorr <11 g/dL) and 600 unexposed pregnant women (HbCorr ≥11 g/dL). We obtained absolute relative frequencies and measures of central tendency. Besides, we compared the qualitative and quantitative variables using the chi-square and the Student t or the Mann-Whitney or Kruskal-Wallis U test, if applicable. We also performed linear regression. Of anemic pregnant women, 68.2% were mild, while only 1% were severe. There was no relationship between HbCorr and neonatal anthropometry, and none of the anemic pregnant women showed a statistical difference in the neonatal anthropometric measures evaluated compared to the unexposed women. There is no relationship between HbCorr and neonatal anthropometry at 3400-m altitude.