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Updated: Dec 18, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
A Case Series of Patients Coinfected With Influenza and COVID-19
Venu Madhav Konala1, Sreedhar Adapa2, Srikanth Naramala2
1Ashland Bellefonte Cancer Center, Ashland, KY, USA.
Insights
Coinfection with COVID-19 and influenza presents a significant health challenge. This case series highlights successful treatment outcomes for two patients with both viral infections.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic with substantial morbidity and mortality.
- Influenza infections are seasonal in the United States, influenced by virus characteristics, vaccine effectiveness, and season duration.
Observation:
- Presents a case series of 3 patients diagnosed with coinfection of COVID-19 and influenza.
- Two of the three patients with coinfection were successfully treated and discharged.
Findings:
- Reviewed existing literature on patients coinfected with both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses.
- Discussed the clinical characteristics and potential treatment strategies for COVID-19 and influenza coinfection.
Implications:
- Understanding coinfection is crucial for managing patients during overlapping respiratory virus seasons.
- Highlights the need for continued research into effective treatment protocols for dual viral infections.
- Informs clinical practice regarding the diagnosis and management of patients presenting with symptoms of both COVID-19 and influenza.
Abstract:
Coronavirus disease 2019, also called COVID-19, is a global pandemic resulting in significant morbidity and mortality worldwide. In the United States, influenza infection occurs mainly during winter and several factors influence the burden of the disease, including circulating virus characteristics, vaccine effectiveness that season, and the duration of the season. We present a case series of 3 patients with coinfection of COVID-19 and influenza, with 2 of them treated successfully and discharged home. We reviewed the literature of patients coinfected with both viruses and discussed the characteristics, as well as treatment options.
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