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Updated: Dec 18, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
New twists on long noncoding RNAs: from mobile elements to motile cancer cells
Tuan M Nguyen1,2, Sumayya Alchalabi3, Adewunmi Oluwatoyosi4
1Harvard Medical School Initiative for RNA Medicine, Harvard Medical School , Boston, MA, USA.
Abstract:
The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.
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