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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in

Matthias Haase1, Anne Thiel2, Ute I Scholl2,3,4

  • 1Division for Specific Endocrinology, Medical Faculty, University Hospital Duesseldorf, Moorenstr 5, 40225, Düsseldorf, Germany. Matthias.Haase@uni-duesseldorf.de.

BMC Research Notes
|June 12, 2020
PubMed
Abstract

Insights

Fibroblast growth factor receptor (FGFR) 2 expression varies in adrenocortical carcinoma (ACC). While not clearly associated with mutations, this suggests FGFR signaling warrants further investigation in ACC treatment.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Fibroblast growth factor receptor (FGFR) 2 regulates adrenal gland development and influences adrenocortical precursor cell proliferation and survival.
  • FGFR2 signaling is implicated in the activation of the Wingless/Int-1 (WNT)/beta-catenin pathway, a known mechanism in adrenocortical carcinoma (ACC) development.

Purpose of the Study:

  • To investigate the role of FGFR2 expression in human adrenocortical carcinoma (ACC).
  • To explore potential correlations between FGFR2 expression, CTNNB1 mutation status, and clinical features in ACC.

Main Methods:

  • A pilot study was conducted analyzing FGFR2 protein expression in 26 ACC samples using immunohistochemistry.
  • CTNNB1 mutation status and clinical data were collected and correlated with FGFR2 expression levels.

Main Results:

  • High variability in FGFR2 expression was observed across different ACC tumor samples.
  • A subset of ACCs exhibited notably high nuclear FGFR2 expression.
  • No clear association was found between FGFR2 expression and CTNNB1 mutational status or clinical characteristics.

Conclusions:

  • FGFR signaling is suggested to play a role in adrenocortical carcinoma.
  • Further research into FGFR signaling in ACC is encouraged, particularly given the availability of FGFR inhibitors in clinical trials for other cancers.
Keywords:
Adrenocortical carcinomaBeta cateninCTNNB1FGFR2

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