Related Experiment Video
Updated: Dec 18, 2025
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An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
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Limb Undergrowth in Intraneural Perineuriomas: An Under-Recognized Association.
Courtney Pendleton1, Karina A Lenartowicz1, B Matthew Howe1
1Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
World Neurosurgery
|June 12, 2020
Summary
Intraneural perineuriomas (IN) are rare nerve tumors. This study found that limb undergrowth, including limb length discrepancy (LLD) and hand/foot size discrepancy (HFD), occurs in 25% of patients, particularly younger ones.
Area of Science:
- Oncology
- Neurology
- Pediatrics
Background:
- Intraneural perineuriomas (IN) are rare, benign, hypertrophic nerve tumors predominantly affecting young individuals.
- Anecdotal evidence suggests a link between IN perineuriomas and limb undergrowth, but this association requires systematic evaluation.
Purpose of the Study:
- To systematically evaluate the incidence of limb undergrowth in patients diagnosed with IN perineuriomas.
- To investigate the correlation between IN perineuriomas and limb length discrepancy (LLD) or hand/foot size discrepancy (HFD).
Main Methods:
- A retrospective review of electronic medical records from 1990 to 2018 was conducted.
- 111 patients with IN perineurioma diagnoses were identified; 108 were included after excluding cranial nerve cases.
- Patients were assessed for documented LLD or HFD, and findings were correlated with tumor location.
Main Results:
- Twenty-seven percent (25.0%) of patients exhibited LLD or HFD.
- Patients with undergrowth were significantly younger at diagnosis (6.14 years) compared to those without (22.9 years).
- Proximal IN perineuriomas showed a significantly higher incidence of LLD or HFD (P < 0.0001) than distal tumors.
Conclusions:
- Limb undergrowth, manifesting as LLD or HFD, is associated with IN perineuriomas and may be under-reported.
- Younger age at diagnosis is a significant factor in patients experiencing undergrowth related to IN perineuriomas.
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