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Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with

J E Blundell1, A J Hill

  • 1Psychology Department, University of Leeds, U.K.

Pharmacology, Biochemistry, and Behavior
|December 1, 1988
PubMed
Summary

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Serotonin-based drugs like d-fenfluramine show potent appetite suppression and weight reduction effects in rats. However, these drugs do not selectively target carbohydrate intake, impacting fat intake equally.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Nutritional Science

Background:

  • Serotoninergic drugs are known for their effects on appetite regulation.
  • Understanding selective suppression of macronutrient intake is crucial for weight management strategies.

Purpose of the Study:

  • To investigate the selective capacity of serotoninergic drugs to suppress carbohydrate intake.
  • To assess the anorexic and weight-reducing effects of d-fenfluramine in rats with diet-induced obesity.

Main Methods:

  • Chronic administration of d-fenfluramine to rats.
  • Rats were fed either a fat-supplemented or carbohydrate-supplemented hyperphagia-inducing diet.
  • Comparison of drug effects between supplemented and control chow-fed rats.

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Main Results:

  • D-fenfluramine demonstrated potent anorexic and weight-reducing effects, particularly in rats on supplemented diets.
  • No evidence of selective inhibition of carbohydrate intake was observed.
  • D-fenfluramine was equally effective in reducing hyperphagia and weight gain induced by both fat and carbohydrate supplements.

Conclusions:

  • D-fenfluramine effectively reduces overall food intake and body weight, irrespective of the macronutrient composition of the hyperphagic diet.
  • The drug does not exhibit selectivity for suppressing carbohydrate consumption over fat consumption.
  • Tolerance to d-fenfluramine was not observed during the 40-day treatment period.