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Retrobulbar chlorpromazine injection in a child with gliosarcoma invasion into the orbits
Franklin Jeng1, Andrew Reynolds2
1Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Insights
This case report details a rare paediatric gliosarcoma invading the orbit. Chlorpromazine injection offered symptomatic relief for a blind, painful eye due to tumor invasion.
Area of Science:
- Neuro-oncology
- Ophthalmology
Background:
- Pediatric gliosarcoma is a rare, aggressive brain tumor variant.
- Orbital invasion by intracranial tumors is uncommon, especially in pediatric cases.
Observation:
- A 12-year-old male presented with headaches, diagnosed with glioblastoma multiforme.
- Tumor recurrence as gliosarcoma led to invasion of the right orbit, causing a blind, painful eye.
Findings:
- This study reports a rare case of pediatric gliosarcoma with orbital invasion.
- Retrobulbar chlorpromazine injection provided immediate symptomatic relief for tumor-induced ocular pain and blindness.
Implications:
- Chlorpromazine injection may be a viable palliative treatment for blind, painful eyes in advanced orbital tumors.
- Highlights the aggressive nature of gliosarcoma and the need for novel therapeutic approaches in pediatric neuro-oncology.
Abstract:
This paper has two main purposes: (1) to report a rare case of paediatric gliosarcoma that invaded the surrounding orbit and (2) to demonstrate chlorpromazine injection as a potential treatment option for blind, painful eye caused by tumour invasion. A 12-year-old man who presented with headaches was found to have glioblastoma multiforme and it was excised and treated with radiation and chemotherapy. Seven months later, the tumour recurred as gliosarcoma, a rare variant of glioblastoma multiforme containing distinct gliomatous and sarcomatous components. In spite of treatment, the tumour progressed and eventually invaded into the right orbit. He subsequently developed a proptotic, blind, painful eye and was treated with retrobulbar chlorpromazine injection, which provided immediate symptomatic relief.
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