Related Experiment Videos
A study of pentylenetetrazol kindling in rats and mice
1Department of Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown 26506.
Pharmacology, Biochemistry, and Behavior
|December 1, 1988
Abstract:
The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determined in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was observed. In mice, it was not possible to demonstrate kindling under experimental conditions utilizing either one or two treatments with PTZ per week.