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Summary
Intratumoral injection of messenger RNA (mRNA) encoding OX40 ligand shows promise for activating the OX40 receptor, offering a new strategy after prior antibody failures.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- OX40 agonist antibodies have faced development challenges.
- Activating the OX40 costimulatory receptor remains a key goal in cancer immunotherapy.