Related Experiment Video
Updated: Dec 18, 2025
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified
María C de Andrés1,2, Mia S Meiss1, Marina Sánchez-Hidalgo3
1Bone and Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Institute of Developmental Science, University of Southampton, Southampton, UK.
Abstract:
Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil-derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology.
Insights
Extra-virgin olive oil polyphenols show anti-inflammatory effects for osteoarthritis treatment. A synthetic derivative of acetylated ligstroside aglycone demonstrated superior potential in reducing cartilage degradation and inflammation.
Area of Science:
- Nutraceuticals
- Pharmacology
- Biochemistry
Background:
- Dietary patterns influence chronic diseases linked to oxidative stress and inflammation.
- Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage degradation.
- Extra-virgin olive oil (EVOO) contains polyphenols with potential therapeutic properties.
Purpose of the Study:
- To investigate the anti-inflammatory effects of EVOO-derived polyphenols, specifically ligstroside aglycone and its acetylated derivative.
- To evaluate their efficacy in attenuating cartilage degradation in osteoarthritis.
- To compare the therapeutic potential of a synthetic acetylated ligstroside aglycone derivative against the natural compound.
Main Methods:
- In vitro assessment of anti-inflammatory profiles of ligstroside aglycone and acetylated ligstroside aglycone.
- Analysis of pro-inflammatory gene expression (NOS2, MMP13) at RNA and protein levels.
- Measurement of nitric oxide release and proteoglycan loss in human OA cartilage explants.
Main Results:
- Both ligstroside aglycone and acetylated ligstroside aglycone exhibited anti-inflammatory properties.
- Acetylated ligstroside aglycone significantly reduced NOS2 and MMP13 expression and nitric oxide release.
- Acetylated ligstroside aglycone markedly decreased proteoglycan loss in human OA cartilage.
Conclusions:
- A novel synthetic acetylated ligstroside aglycone derivative shows enhanced anti-inflammatory activity compared to the natural compound for osteoarthritis.
- These findings support the therapeutic role of nutraceuticals in managing osteoarthritis.
- The study provides insights into osteoarthritis pathophysiology and potential therapeutic interventions.
Related Concept Videos
01:26Atherosclerosis III: Management
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
01:23Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...