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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Coexisting Morbidities in Heart Failure: No Robust Interaction with the Left Ventricular Ejection Fraction
Andrew Xanthopoulos1, Apostolos Dimos1, Grigorios Giamouzis1
1Department of Cardiology, University General Hospital of Larissa, P.O. Box 1425, 411 10, Larissa, Greece.
Current Heart Failure Reports
|June 12, 2020
Summary
Coexisting morbidities are common and significant in heart failure (HF) patients, irrespective of left ventricular ejection fraction (LVEF). These conditions, along with other factors, define the HF patient
Area of Science:
- Cardiology
- Internal Medicine
- Clinical Research
Background:
- Heart failure (HF) is frequently accompanied by multiple coexisting morbidities.
- The prevalence of these comorbidities increases with age in the general population.
Purpose of the Study:
- To review the prevalence and clinical importance of coexisting morbidities in heart failure patients.
- To evaluate the relationship between comorbidities and left ventricular ejection fraction (LVEF) in HF.
Main Methods:
- Review of existing literature on heart failure and comorbidities.
- Analysis of studies examining the impact of LVEF on comorbidity prevalence and significance.
Main Results:
- Coexisting morbidities are highly prevalent and clinically significant in HF patients.
- Differences in comorbidity prevalence across HF with preserved (HFpEF), mid-range (HFmrEF), and reduced LVEF (HFrEF) are minimal or absent.
- No robust evidence supports an interaction between LVEF and the prevalence/significance of comorbidities in HF.
Conclusions:
- Coexisting morbidities are a critical factor in heart failure management, independent of LVEF.
- The combination of comorbidities and other modifiers shapes the HF phenotype and patient outcomes.
- Clinical assessment and management strategies for HF should comprehensively address multimorbidity.
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