Related Experiment Video
Updated: Dec 18, 2025
12:09
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
10.5K
Channels that Cooperate with TRPV4 in the Brain
Na Liu1,2, Jilin Wu3, Yunxia Chen4
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Journal of Molecular Neuroscience : MN
|June 12, 2020
Summary
Transient receptor potential vanilloid 4 (TRPV4) channels interact with other brain receptors. Dysregulation of these interactions contributes to nervous system diseases, offering potential therapeutic targets.
Area of Science:
- Neuroscience
- Molecular Biology
- Channelopathies
Background:
- Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+-permeable cation channel widely expressed in the brain.
- TRPV4 channels are involved in nervous system activity and can be upregulated in pathological conditions, leading to disease.
Purpose of the Study:
- To review cooperative receptors and signaling pathways involving TRPV4 in the brain.
- To elucidate how TRPV4 interactions contribute to nervous system diseases.
- To identify potential therapeutic targets for TRPV4-related brain disorders.
Main Methods:
- Literature review of studies on TRPV4 channel interactions.
- Analysis of cellular signaling pathways involving TRPV4.
- Synthesis of data on TRPV4's role in physiological and pathological conditions.
Main Results:
- TRPV4 cooperates with various channels and receptors, including BKca, NMDARs, AMPARs, IP3Rs, RyRs, and AQP4.
- These interactions are crucial for nervous system function and disease pathogenesis.
- Upregulation and sensitization of TRPV4 contribute to nervous system diseases.
Conclusions:
- TRPV4 plays a significant role in brain function through interactions with other receptors.
- Understanding these cooperative mechanisms is key to developing therapies for neurological diseases.
- Further research into TRPV4 pathways may reveal novel therapeutic strategies.
More Related Videos
10:20Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
8.8K
08:27Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
Published on: January 7, 2019
9.8K
Related Concept Videos
01:12Mechanically-gated Ion Channels
7.4K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.4K
01:43Thermosensation
33.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.4K
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
3.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.6K
01:24Non-gated Ion Channels
7.8K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.8K
01:19The Role of Ion Channels in Neuronal Computation
3.5K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.5K
01:19Ion Channels
90.8K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
90.8K