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Surgical Management of Brain Cavernous Malformations
Marco M Fontanella1, Luca Zanin2, Alessandro Fiorindi2
1Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy. marco.fontanella@unibs.it.
Methods in Molecular Biology (Clifton, N.J.)
|June 12, 2020
Summary
Surgical removal is the primary treatment for cerebral cavernous malformations (CCMs). Careful patient selection and surgical planning are crucial to avoid complications and preserve neurological function, enhancing patient quality of life.
Area of Science:
- Neurosurgery
- Neurology
- Vascular Neurosurgery
Background:
- Cerebral cavernous malformations (CCMs) are vascular malformations in the brain.
- Surgical resection is the only direct therapeutic option for accessible CCM lesions.
Purpose of the Study:
- To outline the essential considerations for surgical intervention in CCMs.
- To detail surgical approaches for various CCM locations.
- To emphasize the importance of preoperative planning and intraoperative monitoring.
Main Methods:
- Clinical, anatomical, and neuroradiological assessment for patient selection.
- Preoperative surgical simulation and quantitative anatomical studies for planning.
- Utilizing neuronavigation, ultrasound, and neurophysiologic monitoring during surgery.
Main Results:
- Surgical approaches vary based on lesion location (supratentorial, infratentorial, deep-seated, brainstem).
- Meticulous planning and advanced technology are key to successful CCM resection.
- Careful consideration of lesion nature and potential deficits is paramount.
Conclusions:
- Surgical management of CCMs requires a comprehensive, individualized approach.
- The goal is complete resection while minimizing neurological and neuropsychological deficits.
- Optimizing surgical strategy improves patient outcomes and quality of life.
