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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Preterm parturition and pre-eclampsia: The confluence of two great gestational syndromes

Aswathi Jayaram1, Charlene H Collier1, James N Martin1

  • 1Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|June 12, 2020
PubMed

Insights

Preterm birth (PTB) and pre-eclampsia are major global health challenges. Coordinating prevention efforts for both conditions is crucial for improving maternal and infant outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Preterm birth (PTB) and pre-eclampsia significantly impact maternal and infant health globally.
  • These conditions often occur together, compounding adverse pregnancy outcomes.

Purpose of the Study:

  • To address the persistent global health challenges posed by PTB and pre-eclampsia.
  • To explore risk factors and potential interventions for these conditions.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane databases.
  • Keywords included spontaneous PTB (SPTB), indicated preterm delivery (IPTD), early-onset pre-eclampsia, and pre-eclampsia.
  • Data search conducted from inception until December 2019.

Main Results:

  • A history of PTB and pre-eclampsia are significant risk factors for subsequent occurrences.
  • Non-Hispanic African American women in the US exhibit higher risks for PTB and pre-eclampsia.
  • Low-dose aspirin (LDA) shows potential in reducing pre-eclampsia (≥10%) and PTB (≥14%).
  • Early-onset pre-eclampsia increases long-term risks for hypertension and cardiovascular disease.

Conclusions:

  • Coordinated prevention strategies for PTB and pre-eclampsia are vital, despite current limitations.
  • Improving maternal safety requires integrated approaches to managing these pregnancy complications.
Abstract

Keywords:
AspirinEclampsiaIndicated preterm birthPre-eclampsiaPreterm birth

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