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Updated: Dec 18, 2025

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

CALIPER Hematology Reference Standards (II).

Victoria Higgins^1,2, Houman Tahmasebi¹, Mary Kathryn Bohn^1,2

¹CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.

American Journal of Clinical Pathology

|June 12, 2020

Summary

This summary is machine-generated.

This study established age- and sex-specific reference intervals for hematologic parameters in healthy children and adolescents. These pediatric-specific reference standards are crucial for accurate interpretation of blood test results in growing individuals.

Keywords:

Beckman Coulter CALIPER Hematology Pediatric Reference intervals

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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Area of Science:

Pediatric Hematology
Clinical Chemistry
Biostatistics

Background:

Accurate interpretation of hematologic parameters in children requires age- and sex-specific reference intervals.
Existing reference ranges may not adequately reflect physiological changes during growth and development.

Purpose of the Study:

To establish comprehensive age- and sex-specific reference intervals for 27 hematologic parameters in the CALIPER cohort of healthy children and adolescents.
To provide a robust pediatric hematology reference database for improved clinical interpretation.

Main Methods:

Analysis of 27 hematologic parameters in 536 healthy children and adolescents (birth to 21 years) using the Beckman Coulter DxH 520 system.
Establishment of age- and sex-specific pediatric reference standards.
Comparison of results with data from a larger laboratory instrument (DxH 900).

Main Results:

Most hematologic parameters exhibited significant age- and/or sex-specific variations.
Age partitioning was necessary for all but four parameters.
Sex partitioning was required for eight parameters.

Conclusions:

This study provides a robust pediatric hematology reference database.
Significant variations in hematologic parameters necessitate the use of pediatric-specific reference standards for accurate interpretation in children and adolescents.