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Updated: Dec 18, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications
Jaroslav Hrenak1, Stefan Zorad, Fedor Simko
1Department of Cardiovascular Surgery, Inselspital - University Hospital of Bern, Bern, Switzerland.
Abstract:
Renin-angiotensin system (RAS) inhibition supposedly increases the expression of angiotensin converting enzyme 2, serving as a binding site for SARS-CoV-2. Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. However, the pharmacological restraining the classical RAS axis might be beneficial due to the reduction of deleterious effects of angiotensin II and enhancement of the anti-inflammatory angiotensin 1-7 pathway. Unless large controlled studies are performed, RAS inhibition remains the cornerstone therapy in populations with cardiovascular disorders.
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