Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.7K

Different outcome of COVID-19 in members of a family

Jin Sun1, Yan Jiang2, Wei Lin3

  • 1Department of Neurobiology, Harbin Medical University, Harbin City, Heilongjiang Province, China. sunjin0524@126.com.

Journal of Infection in Developing Countries
|June 12, 2020
PubMed

Insights

Three family members exposed to SARS-CoV-2 simultaneously showed varied COVID-19 disease manifestations. This study details differing clinical courses and outcomes in a family cluster, highlighting individual responses to the virus.

Area of Science:

  • Virology
  • Infectious Diseases
  • Epidemiology

Background:

  • The rapid spread of coronavirus disease 2019 (COVID-19) necessitates understanding transmission dynamics within households.
  • Family clusters provide unique opportunities to study variations in disease presentation and progression.

Observation:

  • A family cluster involving three members exposed concurrently to SARS-CoV-2 was identified.
  • Clinical manifestations, disease progression, and treatment were documented for the wife and husband.
  • The daughter, despite close contact, remained uninfected, presenting a contrast to infected family members.

Findings:

  • Simultaneous SARS-CoV-2 exposure resulted in differential disease manifestation among family members.
  • Varied clinical presentations and outcomes were observed, even with identical exposure timing.
  • The case of the uninfected daughter suggests potential factors influencing susceptibility or asymptomatic infection.

Implications:

  • Understanding individual variability in COVID-19 response is crucial for public health strategies.
  • Further research into host factors and viral dynamics can elucidate differential disease outcomes.
  • This family cluster study underscores the complexity of SARS-CoV-2 infection dynamics within close-contact settings.

Keywords:
COVID-19SARS-CoV-2coronavirusdisease progressiontreatment

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.7K
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.3K

Related Concept Videos

Relationship with Other Adult Family Members and Siblings01:29

Relationship with Other Adult Family Members and Siblings

Other adult family members and siblings play a crucial role in shaping children’s social and emotional development. While parents or primary caregivers are often the central figures in early attachment and socialization, other adults in a child’s life, such as grandparents, aunts, and uncles, can significantly influence developmental outcomes. These influences depend on each adult’s personality and may help compensate when a primary caregiver is emotionally distant or...
127
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.9K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Contingency Table01:29

Contingency Table

A contingency table provides a way of portraying data that can facilitate calculating probabilities. It is a method of displaying a frequency distribution as a table with rows and columns to show how two variables may be dependent (contingent) upon each other; The table helps determine conditional probabilities quite quickly and can help systematically organize, analyze and quantify data. The table displays sample values concerning two variables that may be dependent or contingent on one...
3.6K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.7K
Family Therapy01:30

Family Therapy

Family therapy conceptualizes psychological challenges as arising from dysfunctional interactions within the family unit, rather than as isolated issues within individuals. This approach seeks to address and transform the patterns of communication, roles, and relationships within families to promote healthier dynamics and emotional well-being for all members.
Strategic Family Therapy
Strategic family therapy emphasizes resolving communication barriers and improving problem-solving abilities...
430