Related Experiment Video
Updated: Dec 18, 2025

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
Published on: November 18, 2022
Successful treatment of aluminium phosphide poisoning by dihydroxyacetone: A two-case report study
Zohereh Oghabian1, Jafar Ahmadi2, Shahrzad Pakravan2
1Pharmaceutical Research Center, Institute of Neuropharmacology and Department of Clinical Toxicology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
What Is Known And Objective:
Aluminium phosphide (AlP) is an agricultural fumigant which produces phosphine gas in the presence of moisture. Phosphine inhibits oxidative phosphorylation and causes cell death by inhibiting cytochrome C oxidase. Clinical manifestations of AlP poisoning are refractory hypotension, tachycardia, low oxygen saturation and severe metabolic acidosis.
Case Summary:
Two cases received dihydroxyacetone (DHA) in addition to routine management of AlP poisoning. Administration of DHA (7 gr in 50 mL sodium bicarbonate, gavage) 2 times at a 1-hour interval improved the clinical signs.
What Is New And Conclusion:
This is the first case report to highlight the safe and successful treatment of AlP poisoning with DHA. However, more clinical studies are recommended to determine the precise mechanism of DHA action.
More Related Videos
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Prevention of Further Absorption of Poison
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Acute Pancreatitis II: Clinical Manifestations and Management
Depolarizing Blockers: Pharmocokinetics
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

