Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 18, 2025

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration

Published on: March 11, 2011

Altering salivary protein profile can decrease aversive oromotor responding to quinine in rats.

Laura E Martin¹, Kristen E Kay², Kimberly F James¹

¹Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14216, USA.

Physiology & Behavior

|June 12, 2020

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Effect of Postural Control on Attentional Resource Allocation in Alzheimer's Disease: An Event-Related Potential Study.

Perceptual and motor skills·2026

Same author

Females experience a greater benefit from surgical resection in an immune-dependent manner in a preclinical glioblastoma model.

Neuro-oncology advances·2026

Same author

Scoping review of episodic future thinking and delay discounting observed in Alzheimer's disease, depression, and PTSD.

Frontiers in psychology·2026

Same author

Androgen loss accelerates brain tumour growth via HPA axis activation.

Nature·2026

Same author

Drinking microstructure analysis of direct controls of water intake in male and female rats.

Physiology & behavior·2026

Same author

Lipocalin 2 orchestrates resistance to ferroptosis via AXL.

Cell reports·2026

Salivary proteins (SPs) can reduce the aversion to bitter tastes like quinine, even without prior exposure. This finding suggests SPs play a key role in modulating bitter taste perception and acceptance.

Area of Science:

Neuroscience
Sensory Science
Physiology

Background:

Bitter taste is often linked to toxins, influencing dietary choices.
Previous studies showed salivary proteins (SPs) upregulated by quinine exposure alter taste perception and feeding behavior.
Existing research couldn't distinguish SP effects from learned responses.

Purpose of the Study:

To investigate if salivary proteins (SPs) can directly alter bitter taste perception in naive animals.
To determine the role of SPs in orosensory feedback independent of dietary learning.

Main Methods:

Collected saliva from rats treated with isoproterenol and pilocarpine.
Analyzed donor saliva for protein concentration and profile.
Infused bitter stimuli (quinine) dissolved in whole saliva, SP-filtered saliva, or water into bitter-naïve rats.

Keywords:

Bitter Diet choice Saliva Taste

More Related Videos

A Novel Behavioral Assay to Investigate Gustatory Responses of Individual, Freely-moving Bumble Bees Bombus terrestris

A Novel Behavioral Assay to Investigate Gustatory Responses of Individual, Freely-moving Bumble Bees Bombus terrestris

Published on: July 21, 2016

A General Method for Evaluating Incubation of Sucrose Craving in Rats

A General Method for Evaluating Incubation of Sucrose Craving in Rats

Published on: November 4, 2011

Related Experiment Videos

Last Updated: Dec 18, 2025

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration

Published on: March 11, 2011

A Novel Behavioral Assay to Investigate Gustatory Responses of Individual, Freely-moving Bumble Bees Bombus terrestris

A Novel Behavioral Assay to Investigate Gustatory Responses of Individual, Freely-moving Bumble Bees Bombus terrestris

Published on: July 21, 2016

A General Method for Evaluating Incubation of Sucrose Craving in Rats

A General Method for Evaluating Incubation of Sucrose Craving in Rats

Published on: November 4, 2011

Quantified orofacial movements to assess taste reactivity.

Main Results:

Quinine increased aversive orofacial movements.
Adding SPs to quinine infusions significantly reduced these aversive responses.
The reduction in aversion was dependent on SP concentration; higher concentrations led to decreased responses.
Whole saliva, but not SP-filtered saliva, altered responses to quinine but not to sour, salty, or sweet stimuli.

Conclusions:

Salivary proteins (SPs) are sufficient to decrease aversive orosensory feedback to bitter stimuli.
The effect of SPs on bitter taste is specific and concentration-dependent.
SPs can modulate bitter taste perception independently of learned associations.