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Updated: Dec 18, 2025

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Current perspectives of osteoclastogenesis through estrogen modulated immune cell cytokines
Isadora Akemi Uehara1, Luiz Ricardo Soldi1, Marcelo José Barbosa Silva1
1Institute of Biomedical Science, Federal University of Uberlandia, Brazil.
Abstract:
Estrogen is a hormone responsible for modulating several physiological processes such as immune response and bone homeostasis. Physiological fluctuations of estrogen concentration are one of the defining principles behind its mechanism. In cases of estrogen deficiency, such as in menopausal women, a more intense bone resorption may occur due to an increase in osteoclast activity. One of the main factors that influence osteoclast formation and response is the immune system, mainly through cytokines secreted by B and T cells. The purpose of this review is to highlight how estrogen can modulate the secretion of cytokines that can alter bone physiology, thereby establishing an axis between estrogen, immune cells, and osteoclastogenesis.
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