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Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
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Lutein Supplementation for Eye Diseases.

Long Hin Li1, Jetty Chung-Yung Lee2, Ho Hang Leung2

  • 1Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Nutrients
|June 13, 2020
PubMed
Summary

Lutein, a xanthophyll carotenoid, is essential for eye health and must be obtained from diet. This review explores lutein

Keywords:
age-related macular degenerationantioxidantcarotenoidcataractdiabetic retinopathymyopianutritionretinaretinopathy of prematurityxanthophyll

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Area of Science:

  • Nutritional Science
  • Ophthalmology
  • Carotenoid Research

Background:

  • Lutein is a vital xanthophyll carotenoid concentrated in the human retina's macula.
  • The human body cannot synthesize lutein, necessitating dietary intake from sources like egg yolks and leafy greens.
  • Lutein possesses demonstrated anti-oxidative and anti-inflammatory properties relevant to ocular health.

Purpose of the Study:

  • To review the chemical structure, properties, and nutritional applications of lutein.
  • To assess the safety and efficacy of lutein as a dietary supplement for eye conditions.
  • To consolidate current research on lutein's impact on various ocular diseases.

Main Methods:

  • Comprehensive literature review of basic and clinical studies on lutein.
  • Analysis of data regarding lutein's anti-oxidative and anti-inflammatory mechanisms.
  • Evaluation of safety profiles and reported side-effects from long-term lutein consumption.

Main Results:

  • Lutein's chemical characteristics support its role in protecting retinal tissues.
  • Evidence suggests lutein's potential benefits in managing age-related macular degeneration, diabetic retinopathy, and cataracts.
  • Lutein is classified as Generally Regarded as Safe (GRAS), indicating a low risk profile for consumers.

Conclusions:

  • Dietary lutein is crucial for maintaining macular health due to the inability of endogenous synthesis.
  • Lutein demonstrates significant potential as a protective and therapeutic agent for numerous eye diseases.
  • Lutein is a safe and effective nutritional supplement for supporting long-term eye health.