Fluostigmine effect on glycogen level in the skeletal muscle

Fluostigmine in a dose not producing evident toxicity reduced the glycogen content in the gastrocnemius muscle in rats, with a consequent decrease of glycogen utilization during contractions of the muscle induced with direct tetanic stimuli. Administration of atropine or atropine with obidoxime failed to change this effect of fluostigmine. The authors suggest that the effect is not due to disturbances of the cholinergic system function.