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Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure

Md Ariful Islam1, Aki Fujisaka2, Junji Kawakami3

  • 1Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.

Bioorganic & Medicinal Chemistry Letters
|June 13, 2020
PubMed

Keywords:
Alkylation reactionOligonucleotidePhosphorothioateStereoselectivity

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