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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric

Michael Frohn1, Longbin Liu1, Aaron C Siegmund1

  • 1Medicinal Chemistry, Amgen Discovery Research, Amgen Inc., Thousand Oaks, CA 91320, United States.

Bioorganic & Medicinal Chemistry Letters
|June 13, 2020
PubMed

Keywords:
(Z)-fluoro-olefinBACE1Bioisostere

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