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Updated: Dec 18, 2025
Purification of a High Molecular Mass Protein in Streptococcus mutans
Published on: September 14, 2019
Complete Genome Sequences of Two Mutacin-Producing Streptococcus mutans Strains, T8 and UA140
1Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA ibiswas@kumc.edu.
Abstract:
Streptococcus mutans is known to produce various antimicrobial peptides called mutacins. Two clinical isolates, T8 and UA140, are well characterized regarding their mutacin production, but genome sequence information was previously unavailable. Complete genome sequences of these two mutacin-producing strains are reported here.
Insights
Complete genome sequences for two Streptococcus mutans strains, T8 and UA140, were determined. These strains are known for producing antimicrobial mutacins, but lacked prior genomic data.
Area of Science:
- Microbiology
- Genomics
- Bacteriology
Background:
- Streptococcus mutans produces antimicrobial peptides known as mutacins.
- Clinical isolates T8 and UA140 are recognized for mutacin production.
- Genome sequence data for these specific isolates were previously unavailable.
Purpose of the Study:
- To obtain and report the complete genome sequences of two significant mutacin-producing Streptococcus mutans clinical isolates, T8 and UA140.
Main Methods:
- Whole-genome sequencing of Streptococcus mutans strains T8 and UA140.
Main Results:
- The complete genome sequences for Streptococcus mutans strains T8 and UA140 have been successfully determined.
- This provides foundational genomic information for these well-characterized mutacin-producing strains.
Conclusions:
- The availability of these genome sequences facilitates further research into mutacin biosynthesis and regulation in Streptococcus mutans.
- This data will aid in understanding the genetic basis of antimicrobial peptide production in these clinical isolates.
