Related Experiment Video
Updated: Dec 18, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
848
New Therapies for Advanced Thyroid Cancer
Diprajan Laha1, Naris Nilubol1, Myriem Boufraqech1
1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Frontiers in Endocrinology
|June 13, 2020
Summary
Thyroid cancer, the most common endocrine cancer, benefits from new biomarkers and targeted therapies. However, advanced, metastatic, iodine-refractory cases still need better treatments.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Thyroid cancer is the most common endocrine malignancy.
- Advances in molecular pathogenesis have enabled personalized treatments.
- Targeted therapies often target oncogenic pathways like MAPK, PI3K/Akt-mTOR, and VEGF.
Observation:
- Despite progress, effective treatments for advanced, metastatic, iodine-refractory thyroid cancer remain limited.
- Genetic alterations and dysregulated pathways are key to understanding thyroid cancer.
- New therapeutic strategies are emerging for difficult-to-treat thyroid cancer.
Findings:
- This review summarizes current knowledge on genetic alterations and dysregulated pathways in thyroid cancer.
- It discusses recent targeted therapies and immunotherapies showing promise for advanced disease.
- Promising anti-tumor activity and clinical benefits are observed with novel treatments.
Implications:
- Understanding molecular pathogenesis is crucial for developing effective thyroid cancer therapies.
- Targeted therapies and immunotherapy offer new hope for patients with advanced, refractory thyroid cancer.
- Continued research into genetic drivers and therapeutic targets will improve patient outcomes.
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