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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

848

New Therapies for Advanced Thyroid Cancer

Diprajan Laha1, Naris Nilubol1, Myriem Boufraqech1

  • 1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Endocrinology
|June 13, 2020
PubMed

Insights

Thyroid cancer, the most common endocrine cancer, benefits from new biomarkers and targeted therapies. However, advanced, metastatic, iodine-refractory cases still need better treatments.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid cancer is the most common endocrine malignancy.
  • Advances in molecular pathogenesis have enabled personalized treatments.
  • Targeted therapies often target oncogenic pathways like MAPK, PI3K/Akt-mTOR, and VEGF.

Observation:

  • Despite progress, effective treatments for advanced, metastatic, iodine-refractory thyroid cancer remain limited.
  • Genetic alterations and dysregulated pathways are key to understanding thyroid cancer.
  • New therapeutic strategies are emerging for difficult-to-treat thyroid cancer.

Findings:

  • This review summarizes current knowledge on genetic alterations and dysregulated pathways in thyroid cancer.
  • It discusses recent targeted therapies and immunotherapies showing promise for advanced disease.
  • Promising anti-tumor activity and clinical benefits are observed with novel treatments.

Implications:

  • Understanding molecular pathogenesis is crucial for developing effective thyroid cancer therapies.
  • Targeted therapies and immunotherapy offer new hope for patients with advanced, refractory thyroid cancer.
  • Continued research into genetic drivers and therapeutic targets will improve patient outcomes.
Keywords:
RAI-refractoryadvanced thyroid cancerimmunotherapytargeted therapiesthyroid cancer

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