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Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles
Jonathan M Carnino1, Kareemah Ni1, Yang Jin1
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, MA, United States.
Frontiers in Immunology
|June 13, 2020
Summary
Post-translational modifications (PTMs) control which non-coding RNAs and proteins are packaged into extracellular vesicles (EVs). This selection influences the function of EVs and their cargo in cell communication.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Extracellular vesicles (EVs) mediate intercellular communication by transferring molecules like non-coding RNAs.
- Post-translational modifications (PTMs) are increasingly recognized as key regulators in biological processes.
Purpose of the Study:
- To review the role of PTMs in the selection of non-coding RNAs and proteins into eukaryotic EVs.
- To highlight how PTMs influence EV-mediated intercellular communication.
Main Methods:
- Literature review focusing on PTMs, non-coding RNAs, and extracellular vesicles.
- Analysis of existing studies on EV biogenesis and cargo selection.
Main Results:
- PTMs critically regulate the specific loading of non-coding RNAs and proteins into EVs.
- These modifications impact the functional outcomes of EV transfer and cargo activity.
Conclusions:
- PTMs are essential for determining the molecular composition of EVs.
- Understanding PTM-mediated EV cargo selection is vital for deciphering intercellular communication and EV-based therapeutics.
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