Related Experiment Video

Updated: Dec 18, 2025

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways
10:06

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

Published on: December 13, 2024

725

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

Jeanne Bigot1, Loïc Guillot2, Juliette Guitard1

  • 1Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, France.

Frontiers in Immunology
|June 13, 2020
PubMed

Insights

This review details the bronchial epithelial cells' innate immune response to Aspergillus fumigatus, a common airborne fungus causing various human infections. It highlights the critical role of these cells in the initial host defense against fungal invasion.

Area of Science:

  • Pulmonology
  • Mycology
  • Immunology

Background:

  • Aspergillus fumigatus is a widespread fungus causing human diseases from allergies to invasive infections.
  • Inhalation of fungal conidia leads to initial host interaction with bronchial epithelial cells.
  • While alveolar macrophages are studied, bronchial epithelium's role in Aspergillus-lung interactions is increasingly recognized.

Purpose of the Study:

  • To review the innate immune response of bronchial epithelial cells against Aspergillus fumigatus.
  • To detail molecular interactions between bronchial epithelial cells and A. fumigatus.
  • To elucidate the effects of different interaction modes on these cells.

Main Methods:

  • Literature review focusing on innate immunity and bronchial epithelial cells.
  • Analysis of molecular mechanisms in host-fungus interactions.
  • Synthesis of data on cellular responses to A. fumigatus.

Main Results:

  • Bronchial epithelial cells mount an innate immune response to A. fumigatus.
  • Specific molecular pathways and interactants are identified.
  • Different fungal interaction modes elicit distinct cellular responses.

Conclusions:

  • Bronchial epithelial cells are crucial in the early defense against Aspergillus fumigatus.
  • Understanding these interactions is key to managing fungal lung diseases.
  • Further research into epithelial cell responses can inform therapeutic strategies.
Keywords:
Aspergillus fumigatusbronchial epithelial cellsinnate immunitylung infectionmucociliary machinery

More Related Videos

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.7K
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

10.9K

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
5.7K
Alveoli and Alveolar Ducts01:26

Alveoli and Alveolar Ducts

The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
5.0K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.0K