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Updated: Dec 18, 2025

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Soft Tissue: A Possible Source of Pain Pre and Post Minimally Invasive Spine Surgery
Norman J Marcus1, Franziska A Schmidt2,3
1Weill Cornell Center for Comprehensive Spine Care, New York, NY, USA.
Study Design:
Case studies.
Objectives:
To demonstrate that muscle generated pain (MGP) may be a cause of pain in patients who have undergone minimally invasive spine surgery (MISS).
Methods:
A physical examination including electrical stimulation of putative pain generating muscles to identify the presence of lowered thresholds for depolarization of muscle nociceptors, and an examination of strength and flexibility of key muscles in the upper and lower body, may identify multiple etiologies of MGP. Treatment of identified muscles consisted of muscle/tendon injections to identified sensitized muscles followed by exercises incorporating relaxation limbering and stretching.
Results:
Postsurgical pain was eliminated and mobility restored in both presented cases replicating success in prior published studies.
Conclusions:
Understanding the pathophysiological mechanisms of muscle pain may facilitate the evaluation and treatment of MGP in MISS patients diagnosed with failed back surgery syndrome.

