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Antineoplastic Agents Targeting Sphingolipid Pathways.

Alexander Kroll1, Hwang Eui Cho2,3, Min H Kang2,3

  • 1School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

Frontiers in Oncology
|June 13, 2020
PubMed
Summary
This summary is machine-generated.

Sphingolipids, once structural, are now key signaling molecules in cancer. Targeting their metabolism offers new avenues for cancer chemotherapy and diagnostics.

Keywords:
ceramideslipid biomarkerssphingolipidssphingomyelinsphingosine-1-phosphate

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Sphingolipids and metabolites have diverse cellular functions beyond structure.
  • They are critical in cellular signaling, influencing cancer cell death, survival, inflammation, and oncogenesis.

Purpose of the Study:

  • To review current chemotherapeutic agents targeting sphingolipid metabolism in clinical trials.
  • To identify research questions regarding sphingolipid metabolism as a chemotherapeutic target.

Main Methods:

  • Literature review of clinical trials.
  • Analysis of sphingolipid metabolism in cancer.

Main Results:

  • Dysregulation of sphingolipid metabolism is common in tumors.
  • Sphingolipid profiles can predict tumor presence, drug susceptibility, and metastasis.

Conclusions:

  • Sphingolipid metabolism is crucial for cancer diagnostics and chemotherapy.
  • Further research is needed on targeting sphingolipid metabolism in cancer treatment.