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Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

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The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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Administering Oxygen by Nasal Cannula01:29

Administering Oxygen by Nasal Cannula

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Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
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Administering Oxygen by Mask01:30

Administering Oxygen by Mask

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Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
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Related Experiment Video

Updated: Dec 18, 2025

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
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Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia.

Tai-En Hsieh1, Sheng-Ju Lin1, Li-Chi Chen1,2

  • 1Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

Frontiers in Bioengineering and Biotechnology
|June 13, 2020
PubMed
Summary
This summary is machine-generated.

Injectable microparticles deliver oxygen to promote bone healing. This system relieves hypoxia in bone cells, enhancing their differentiation and improving fracture repair.

Keywords:
PLGA microparticleshypoxiahypoxia-inducible factoroxygen-generating biomaterialsperoxide

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Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
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Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Bone fractures cause oxygen deficiency, leading to cell death and delayed bone healing.
  • Enhancing local oxygen levels is crucial for promoting bone regeneration.
  • Current treatments for impaired fracture healing require improvement.

Purpose of the Study:

  • To develop an injectable oxygen-generating system for enhanced bone fracture healing.
  • To investigate the properties and efficacy of calcium peroxide/manganese dioxide-encapsulated poly lactic-co-glycolic acid microparticles (CaO2 + MnO2@PLGA MPs).
  • To assess the impact of these microparticles on cellular responses under hypoxic conditions.

Main Methods:

  • Fabrication of CaO2 + MnO2@PLGA MPs for localized oxygen delivery.
  • In vitro assessment of oxygen release profiles and component cytotoxicity.
  • Evaluation of the effect of MPs on preosteoblast MC3T3-E1 cell hypoxia and osteogenic differentiation.

Main Results:

  • Optimized CaO2 + MnO2@PLGA MPs demonstrated controlled oxygen release.
  • The microparticles effectively alleviated hypoxia in MC3T3-E1 cells.
  • Significant promotion of osteogenic differentiation in preosteoblast cells was observed.

Conclusions:

  • The developed CaO2 + MnO2@PLGA MPs show potential as an injectable therapeutic for fracture healing.
  • Local oxygen delivery via these microparticles can overcome hypoxia-induced healing impairments.
  • This approach holds promise for enhancing bone regeneration by improving tissue oxygenation.