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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
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A to Z of Zika Virus: A Comprehensive Review for Clinicians

Harbir Singh Arora1,2

  • 1Children's Hospital of Michigan, Detroit, MI, USA.

Global Pediatric Health
|June 13, 2020
PubMed

Insights

Zika virus, known for its neurotropic effects, spread to the Americas in 2015, causing microcephaly in infants. Prevention of Zika virus transmission in pregnant women is crucial.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Zika virus, first identified in 2007, spread globally, reaching the Americas in 2015.
  • The virus gained notoriety for its neurotropic characteristics and association with congenital abnormalities, particularly microcephaly, during the 2015 Brazil outbreak.
  • Understanding the long-term outcomes for infants infected with Zika virus during gestation has evolved since the initial outbreak.

Purpose of the Study:

  • To provide a comprehensive review of Zika virus infection.
  • To detail the history, transmission, diagnosis, pathophysiology, complications, and prevention strategies for Zika virus.
  • To emphasize the importance of preventing Zika virus transmission in pregnant women.

Main Methods:

  • This review synthesizes information from existing studies and literature.
  • It covers the epidemiological spread and clinical manifestations of Zika virus.
  • The review includes diagnostic approaches, pathological mechanisms, and preventative measures.

Main Results:

  • Zika virus exhibits neurotropic properties, impacting fetal development.
  • A significant increase in microcephaly and congenital deformities was observed in infants born to mothers infected during pregnancy.
  • Long-term outcomes for affected infants are increasingly understood.

Conclusions:

  • Zika virus poses a significant threat, especially to pregnant women and their offspring.
  • Effective prevention of transmission is paramount to mitigating the impact of Zika virus.
  • Continued research and public health vigilance are necessary to manage Zika virus infection.
Keywords:
CKZZIKVZika viruscongenital Zika syndromediagnosis of Zikapregnancyprevention of Zikatransmission of Zika

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